The MLH1 −93 promoter variant influences gene expression
نویسندگان
چکیده
منابع مشابه
Lynch Syndrome Associated with Two MLH1 Promoter Variants and Allelic Imbalance of MLH1 Expression
Lynch syndrome is a hereditary cancer syndrome caused by a constitutional mutation in one of the mismatch repair genes. The implementation of predictive testing and targeted preventative surveillance is hindered by the frequent finding of sequence variants of uncertain significance in these genes. We aimed to determine the pathogenicity of previously reported variants (c.-28A>G and c.-7C>T) wit...
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ژورنال
عنوان ژورنال: Cancer Epidemiology
سال: 2010
ISSN: 1877-7821
DOI: 10.1016/j.canep.2009.12.009